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Functional CD40 (mouse) Antibody, mAb (preservative free)

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P27513
Reactivity Mouse
Host Purified From Concentrated Hybridoma Tissue Culture Supernatant.
Clonality Monoclonal
Isotype Rat IgG2a
Gene Source Mouse
Endotoxin <0.01EU/ µg purified protein (LAL test; Lonza).
Application Note ,FC,Functional Application, Activates B and NK cells in vivo and in vitro .
Clone Names FGK45
Description Widely used stimulatory MAb to CD40. Shown to indirectly activate natural killer (NK) cells, producing significant antitumor and antimetastatic effects. Effective in boosting immune responses against infectious agents and can potentially be used to treat chronic autoimmune inflammatory processes.
Additional Information
Other Names Tumor Necrosis Factor Receptor Superfamily Member 5; CD40L Receptor
Target/Specificity Recognizes mouse CD40.
Format Liquid. In PBS containing 0.02% sodium azide.
Reconstitution & Storage Stable for at least 1 year after receipt when stored at -20°C.
PrecautionsFunctional CD40 (mouse) Antibody, mAb (preservative free) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Research Areas
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CD40 belongs to the TNF-receptor superfamily and is essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. The interaction of CD40-CD40L is necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. CD40 is constitutively expressed by antigen presenting cells, including dendritic cells, B cells and macrophages. Consistent with its widespread expression on normal cells, CD40 is also expressed on a wide range of tumor cells, including non-Hodgkin's and Hodgkin's lymphomas, myeloma and some carcinomas including nasopharynx, bladder, cervix, kidney and ovary.

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$ 150.00
$ 380.00
Cat# ADP0025
(40 western blots)
Availability: 3-5 days
Bulk Size
Seasonal Special on Bulk Order
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