|Application ||FC, E|
|Host||Purified From HEK 293 Cell culture Supernatant.|
|Endotoxin||<0.01EU/ µg purified protein (LAL-test; Lonza).|
|Calculated MW||45645 Da|
|Description||IL-1R2 (mouse) monoclonal antibody (recombinant) (Praxy-1-1) is composed of human variable regions (VH and VL) (λ-chain) of immunoglobulin fused to the mouse IgG2b Fc domain.|
|Other Names||CD121 Antigen-like Family Member B; IL-1 Type II Receptor; Interleukin-1 Receptor β Interleukin-1 Receptor Type II; CD121b|
|Target/Specificity||Recognizes mouse IL-1R2.|
|Format||Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.|
|Reconstitution & Storage||Stable for at least 1 month after receipt when stored at +4°C. Stable for at least 1 year after receipt when stored at -20°C.|
|Precautions||Functional IL-1R2 (mouse) Antibody, mAb (recombinant) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors (By similarity).|
|Cellular Location||Membrane; Single-pass type I membrane protein. Cell membrane. Secreted|
|Tissue Location||Strongly expressed in B-cells, with levels 21 times higher than IL1R1. In T-cells expressed 5 times more compared with IL1R1.|
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Provided below are standard protocols that you may find useful for product applications.
The inflammatory actions of IL-1α and -β- depend on their interaction with its receptor, IL-1R1, and can be negatively controlled by several inhibitors such as IL-1Ra, IL-1R type 2 (IL-1R2), SIGIRR and the soluble form of IL-1 receptor accessory protein (IL-1RAcP). IL-1R2 neutralizes IL-1 either as a surface decoy receptor or in a cleaved and secreted form. IL-1R2 is expressed on B cells, on neutrophils and on in vitro expanded human Tregs.
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