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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Cofilin Antibody (S3)   

Cofilin Antibody (S3)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - Cofilin  Antibody (S3) AE1009a
    Western blot analysis of extracts from COLO 205 cells using Cofilin Antibody (S3) (#AE1009a, Lane 1 and 2) and Phospho-Cofilin-S3 Antibody (#AE1009b, Lane 3 and 4).
  • IHC - Cofilin  Antibody (S3) AE1009a
    Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Cofilin Antibody (S3) (#AE1009a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P23528
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Concentration 1mg/ml
Isotype Rabbit IgG
Calculated MW 18502 Da
Additional Information
Gene ID 1072
Other Names Cofilin-1, 18 kDa phosphoprotein, p18, Cofilin, non-muscle isoform, CFL1, CFL
Target/Specificity The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Dilution WB~~1:500~1:1000
Format affinity Purified IgG, in PBS, 0.02% sodium azide and 50% glycerol.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCofilin Antibody (S3) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CFL1
Synonyms CFL
Function Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation.
Cellular Location Nucleus matrix. Cytoplasm, cytoskeleton. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium membrane; Peripheral membrane protein; Cytoplasmic side. Note=Colocalizes with the actin cytoskeleton in membrane ruffles and lamellipodia. Detected at the cleavage furrow and contractile ring during cytokinesis. Almost completely in nucleus in cells exposed to heat shock or 10% dimethyl sulfoxide
Tissue Location Widely distributed in various tissues.
Research Areas
Citations (0)

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Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.


Actin-depolymerizing factor cofilin-1 is necessary in maintaining mature podocyte architecture. Garg P, et al. J Biol Chem, 2010 Jul 16. PMID 20472933.
Proteome analysis of the thalamus and cerebrospinal fluid reveals glycolysis dysfunction and potential biomarkers candidates for schizophrenia. Martins-de-Souza D, et al. J Psychiatr Res, 2010 May 14. PMID 20471030.
Sex-specific proteome differences in the anterior cingulate cortex of schizophrenia. Martins-de-Souza D, et al. J Psychiatr Res, 2010 Apr 8. PMID 20381070.
HUNK suppresses metastasis of basal type breast cancers by disrupting the interaction between PP2A and cofilin-1. Quintela-Fandino M, et al. Proc Natl Acad Sci U S A, 2010 Feb 9. PMID 20133759.
Tyrosine phosphorylation of cofilin at Y68 by v-Src leads to its degradation through ubiquitin-proteasome pathway. Yoo Y, et al. Oncogene, 2010 Jan 14. PMID 19802004.

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$ 325.00
Cat# AE1009a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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