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Phospho-Ezrin-T567 AntibodyPurified Rabbit Polyclonal Antibody (Pab)
| Country | United States
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| Catalog # | Size | Availability | Price | |
| AE1012b | 0.1 mg 400 ul | 7-10 days | $ 325.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
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- Backgrounds
Phospho-Ezrin-T567 Antibody - Product info | |
| Application | WB
|
| Primary Accession | P15311 |
| Reactivity | Human, Mouse, Rat |
| Concentration | 1mg/ml |
| Isotype | Rabbit IgG |
| Calculated MW | 69413 Da |
Phospho-Ezrin-T567 Antibody - Additional info | |
| Gene ID 7430 | |
| Other Names Villin-2; Cytovillin; p81; Ezrin | |
| Target/Specificity The antibody was affinity-purified from rabbit antiserum using epitope-specific phosphopeptide column, and the antibody against non-phosphopeptide was removed using non-phosphopeptide column corresponding to the phosphorylation site. | |
| Dilution WB~~1:500~1:1000 | |
| Format affinity Purified IgG, in PBS, 0.02% sodium azide and 50% glycerol. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions Phospho-Ezrin-T567 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. | |
Phospho-Ezrin-T567 Antibody - Protein Information | |
| Name EZR | |
| Synonyms VIL2 | |
| Function Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis | |
| Cellular Location Apical cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection. Cell projection, microvillus membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Note=Localization to the apical membrane of parietal cells depends on the interaction with MPP5. Localizes to cell extensions and peripheral processes of astrocytes (By similarity) Microvillar peripheral membrane protein (cytoplasmic side) | |
| Tissue Location Expressed in cerebral cortex, basal ganglia, hippocampus, hypophysis, and optic nerve. Weakly expressed in brain stem and diencephalon. Stronger expression was detected in gray matter of frontal lobe compared to white matter (at protein level). Component of the microvilli of intestinal epithelial cells. Preferentially expressed in astrocytes of hippocampus, frontal cortex, thalamus, parahippocampal cortex, amygdala, insula, and corpus callosum. Not detected in neurons in most tissues studied | |
Phospho-Ezrin-T567 Antibody - Application data
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Western blot analysis of extracts from A431 cells, untreated or EGFtreated (200ng/ml, 30min) using Ezrin Antibody (T567) (#AE1012a, Lane 1 and 2) and Phospho-Ezrin-T567 Antibody (#AE1012b, Lane 3 and 4).
Phospho-Ezrin-T567 Antibody - Related products
AP5845a: EZRIN Antibody (N-term)
BP5845a: EZRIN Antibody (N-term) Blocking peptide
AT4512a: VIL2 Antibody (monoclonal) (M04)
AJ1279c: Ezrin Antibody Phospho (pY353)
AJ1279d: Ezrin/Radixin/Moesin Antibody
AF1389a: Ezrin / villin 2 Antibody
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BACKGROUND
The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene.
REFERENCES
Ezrin immunoreactivity in renal cell carcinomas. Tuna B, et al. Anal Quant Cytol Histol, 2009 Oct. PMID 20701102. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility hot-spot. Johnatty SE, et al. PLoS Genet, 2010 Jul 8. PMID 20628624. Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086. Immunoexpression of Ezrin and CD44 in patients with osteosarcoma. Boldrini E, et al. J Pediatr Hematol Oncol, 2010 Aug. PMID 20562647. Ezrin immunohistochemical expression in chondrosarcomas, osteosarcomas and Ewing sarcoma family of tumors. Machado I, et al. Virchows Arch, 2010 Jul. PMID 20552365.
