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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   IRS-1 Antibody (S636)   

IRS-1 Antibody (S636)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - IRS-1  Antibody (S636) AE1018a
    Western blot analysis of extracts from 293 cells treated with insulin(100nM, 30min) or PMA (0.2?M, 15min) using IRS-1 Antibody (S636) (#AE1018a, Lane 1, 2 and 3) and Phospho-IRS-1-S636 Antibody (#AE1018c, Lane 4, 5 and 6).
  • IHC - IRS-1  Antibody (S636) AE1018a
    Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using IRS-1 Antibody (S636) (#AE1018a).
  • IF - IRS-1  Antibody (S636) AE1018a
    Immunofluorescence staining of methanol-fixed HeLa cells using IRS-1 Antibody (S636) (#AE1018a,Red).
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC, IF
Primary Accession P35568
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Concentration 1mg/ml
Isotype Rabbit IgG
Calculated MW 131591 Da
Additional Information
Gene ID 3667
Other Names Insulin receptor substrate 1, IRS-1, IRS1
Target/Specificity The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Dilution WB~~1:500~1:1000
IHC~~1:50~1:100
IF~~1:100~200
Format affinity Purified IgG, in PBS, 0.02% sodium azide and 50% glycerol.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsIRS-1 Antibody (S636) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IRS1
Function May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity).
Research Areas
Citations (0)

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Background

This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance.

References

COMMON VARIANTS IN 40 GENES ASSESSED FOR DIABETES INCIDENCE AND RESPONSE TO METFORMIN AND LIFESTYLE INTERVENTIONS IN THE DIABETES PREVENTION PROGRAM. Jablonski KA, et al. Diabetes, 2010 Aug 3. PMID 20682687.
A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM). Romero R, et al. Am J Obstet Gynecol, 2010 Jul 29. PMID 20673868.
Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolism and breast cancer risk in the NCI breast and prostate cancer cohort consortium. Canzian F, et al. Hum Mol Genet, 2010 Oct 1. PMID 20634197.
Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.
Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? Rua帽o G, et al. Pharmacogenomics, 2010 Jul. PMID 20602615.

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$ 325.00
Cat# AE1018a
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