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Goat Anti-14-3-3 sigma / Stratifin Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-14-3-3 sigma / Stratifin Antibody AF1001a
    AF1001a (0.1 µg/ml) staining of human skin lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
  • IHC - Goat Anti-14-3-3 sigma / Stratifin Antibody AF1001a
    AF1001a (2µg/ml) staining of paraffin embedded Human Skin. Steamed antigen retrieval with Tris/EDTA buffer pH 9, HRP-staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P31947
Other Accession NP_006133, 2810, 55948 (mouse), 313017 (rat)
Reactivity Human
Predicted Mouse, Rat, Pig, Dog
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 27774 Da
Additional Information
Gene ID 2810
Other Names 14-3-3 protein sigma, Epithelial cell marker protein 1, Stratifin, SFN, HME1
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-14-3-3 sigma / Stratifin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SFN
Synonyms HME1
Function Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53.
Cellular Location Cytoplasm. Nucleus. Secreted. Note=May be secreted by a non-classical secretory pathway
Tissue Location Present mainly in tissues enriched in stratified squamous keratinizing epithelium
Research Areas
Citations (0)

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Hypermethylated 14-3-3-sigma and ESR1 gene promoters in serum as candidate biomarkers for the diagnosis and treatment efficacy of breast cancer metastasis. Zurita M, et al. BMC Cancer, 2010 May 20. PMID 20487521.
The expression of seven 14-3-3 isoforms in human meningioma. Liu Y, et al. Brain Res, 2010 Jun 8. PMID 20388496.
[Expression and clinical significance of 14-3-3 sigma and heat shock protein 27 in colorectal cancer] Pei HP, et al. Zhonghua Wei Chang Wai Ke Za Zhi, 2010 Mar. PMID 20336542.
Reduced stratifin expression can serve as an independent prognostic factor for poor survival in patients with esophageal squamous cell carcinoma. Ren HZ, et al. Dig Dis Sci, 2010 Sep. PMID 20108042.
Up-regulation of 14-3-3sigma (Stratifin) is associated with high-grade CIN and high-risk human papillomavirus (HPV) at baseline but does not predict outcomes of HR-HPV infections or incident CIN in the LAMS study. Syrj脌nen S, et al. Am J Clin Pathol, 2010 Feb. PMID 20093232.

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$ 325.00
Cat# AF1001a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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