|Application ||WB, E|
|Other Accession||NP_006817, 10971|
|Predicted||Mouse, Rat, Dog|
|Calculated MW||27764 Da|
|Other Names||14-3-3 protein theta, 14-3-3 protein T-cell, 14-3-3 protein tau, Protein HS1, YWHAQ|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-14-3-3 tau / YWHAQ Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.|
|Cellular Location||Cytoplasm. Note=In neurons, axonally transported to the nerve terminals|
|Tissue Location||Abundantly expressed in brain, heart and pancreas, and at lower levels in kidney and placenta. Up-regulated in the lumbar spinal cord from patients with sporadic amyotrophic lateral sclerosis (ALS) compared with controls, with highest levels of expression in individuals with predominant lower motor neuron involvement.|
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Provided below are standard protocols that you may find useful for product applications.
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the repeat number and the disease.
Aurora B and 14-3-3 coordinately regulate clustering of centralspindlin during cytokinesis. Douglas ME, et al. Curr Biol, 2010 May 25. PMID 20451386.
The expression of seven 14-3-3 isoforms in human meningioma. Liu Y, et al. Brain Res, 2010 Jun 8. PMID 20388496.
The PX-RICS-14-3-3zeta/theta complex couples N-cadherin-beta-catenin with dynein-dynactin to mediate its export from the endoplasmic reticulum. Nakamura T, et al. J Biol Chem, 2010 May 21. PMID 20308060.
Protein phosphatase 2A reactivates FOXO3a through a dynamic interplay with 14-3-3 and AKT. Singh A, et al. Mol Biol Cell, 2010 Mar. PMID 20110348.
14-3-3Tau regulates ubiquitin-independent proteasomal degradation of p21, a novel mechanism of p21 downregulation in breast cancer. Wang B, et al. Mol Cell Biol, 2010 Mar. PMID 20086099.
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