|Application ||WB, IHC, IF, ICC, E|
|Other Accession||NP_005836, 10257, 170924 (rat)|
|Calculated MW||149527 Da|
|Other Names||Multidrug resistance-associated protein 4, ATP-binding cassette sub-family C member 4, MRP/cMOAT-related ABC transporter, Multi-specific organic anion transporter B, MOAT-B, ABCC4, MRP4|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-ABCC4 / MRP4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be an organic anion pump relevant to cellular detoxification.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Widely expressed, with particularly high levels in prostate, but is barely detectable in liver|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in cellular detoxification as a pump for its substrate, organic anions. Alternative splicing results in multiple splice variants encoding different isoforms.
Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086. A Japanese-specific allele in the GALNT11 gene. Yuasa I, et al. Leg Med (Tokyo), 2010 Jul. PMID 20547088. Aryl hydrocarbon receptor and NF-E2-related factor 2 are key regulators of human MRP4 expression. Xu S, et al. Am J Physiol Gastrointest Liver Physiol, 2010 Jul. PMID 20395535. The multidrug-resistance protein 4 polymorphism is a new factor accounting for thiopurine sensitivity in Japanese patients with inflammatory bowel disease. Ban H, et al. J Gastroenterol, 2010 Apr 15. PMID 20393862. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
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