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Goat Anti-ABCD1 Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-ABCD1 Antibody AF1011a
    HEK293 overexpressing human ABCD1 and probed with AF1011a at 1ug/ml (mock transfection in first lane).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P33897
Other Accession NP_000024, 215
Reactivity Human
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 82937 Da
Additional Information
Gene ID 215
Other Names ATP-binding cassette sub-family D member 1, Adrenoleukodystrophy protein, ALDP, ABCD1, ALD
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-ABCD1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ABCD1
Synonyms ALD
Function Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity.
Cellular Location Peroxisome membrane; Multi-pass membrane protein
Research Areas
Citations (0)

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The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein is likely involved in the peroxisomal transport or catabolism of very long chain fatty acids. Defects in this gene have been identified as the underlying cause of adrenoleukodystrophy, an X-chromosome recessively inherited demyelinating disorder of the nervous system.


Identification of novel SNPs of ABCD1, ABCD2, ABCD3, and ABCD4 genes in patients with X-linked adrenoleukodystrophy (ALD) based on comprehensive resequencing and association studies with ALD phenotypes. Matsukawa T, et al. Neurogenetics, 2010 Jul 27. PMID 20661612.
[A novel missense mutation resulting in X-linked adrenoleukodystrophy in female heterozygotes of a Chinese family] Xie HH, et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 2010 Apr. PMID 20376793.
Spinocerebellar variant of adrenoleukodystrophy with a novel ABCD1 gene mutation. Li JY, et al. J Neurol Sci, 2010 Mar 15. PMID 20042197.
Downregulation of ABCD1 in human renal cell carcinoma. Hour TC, et al. Int J Biol Markers, 2009 Jul-Sep. PMID 19787628.
Three novel variants in X-linked adrenoleukodystrophy. Shukla P, et al. J Child Neurol, 2009 Jul. PMID 19406751.

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$ 325.00
Cat# AF1011a
(40 western blots)
Availability: 7-10 days
Bulk Size
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