|Application ||WB, E|
|Other Accession||NP_001035809, 6059, 24015 (mouse), 361390 (rat)|
|Predicted||Mouse, Rat, Dog, Cow|
|Calculated MW||67314 Da|
|Other Names||ATP-binding cassette sub-family E member 1, 2'-5'-oligoadenylate-binding protein, HuHP68, RNase L inhibitor, Ribonuclease 4 inhibitor, RNS4I, ABCE1, RLI, RNASEL1, RNASELI, RNS4I|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-ABCE1/ RNAse L inhibitor Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||RLI, RNASEL1, RNASELI, RNS4I|
|Function||Antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly.|
|Cellular Location||Cytoplasm. Mitochondrion. Note=Localized to clusters of virus formation at the plasma membrane|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action. Two transcript variants encoding the same protein have been found for this gene.
A small interfering ABCE1-targeting RNA inhibits the proliferation and invasiveness of small cell lung cancer. Huang B, et al. Int J Mol Med, 2010 May. PMID 20372810.
The role of ABCE1 in eukaryotic posttermination ribosomal recycling. Pisarev AV, et al. Mol Cell, 2010 Jan 29. PMID 20122402.
An excess of rare genetic variation in ABCE1 among Yorubans and African-American individuals with HIV-1. Crawford DC, et al. Genes Immun, 2009 Dec. PMID 19657357.
Defining the human deubiquitinating enzyme interaction landscape. Sowa ME, et al. Cell, 2009 Jul 23. PMID 19615732.
Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. Saito A, et al. J Hum Genet, 2009 Jun. PMID 19343046.
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