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Goat Anti-ACO1 / Aconitase 1 Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-ACO1 / Aconitase 1 Antibody AF1018a
    AF1018a (0.1 µg/ml) staining of Human Liver lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P21399
Other Accession NP_002188, 48, 11428 (mouse), 50655 (rat)
Reactivity Human
Predicted Mouse, Rat, Cow
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 98399 Da
Additional Information
Gene ID 48
Other Names Cytoplasmic aconitate hydratase, Aconitase,, Citrate hydro-lyase, Ferritin repressor protein, Iron regulatory protein 1, IRP1, Iron-responsive element-binding protein 1, IRE-BP 1, ACO1, IREB1
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-ACO1 / Aconitase 1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ACO1
Synonyms IREB1
Function Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding.
Cellular Location Cytoplasm.
Research Areas
Citations (0)

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Aconitase 1, also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. Thus, IREB1 plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes.


Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations. Yang XR, et al. Fam Cancer, 2010 Jun 24. PMID 20574843.
Interaction of iron regulatory protein-1 (IRP-1) with ATP/ADP maintains a non-IRE-binding state. Popovic Z, et al. Biochem J, 2010 Sep 1. PMID 20569198.
The connectivity map links iron regulatory protein-1-mediated inhibition of hypoxia-inducible factor-2a translation to the anti-inflammatory 15-deoxy-delta12,14-prostaglandin J2. Zimmer M, et al. Cancer Res, 2010 Apr 15. PMID 20354189.
An E3 ligase possessing an iron-responsive hemerythrin domain is a regulator of iron homeostasis. Salahudeen AA, et al. Science, 2009 Oct 30. PMID 19762597.
Control of iron homeostasis by an iron-regulated ubiquitin ligase. Vashisht AA, et al. Science, 2009 Oct 30. PMID 19762596.

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$ 325.00
Cat# AF1018a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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