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Goat Anti-ADAM12 Antibody

Peptide-affinity purified goat antibody

  • IHC - Goat Anti-ADAM12 Antibody AF1025a
    AF1025a (3.8 µg/ml) staining of paraffin embedded Human Prostate. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
  • WB - Goat Anti-ADAM12 Antibody AF1025a
    AF1025a staining (0.1 µg/ml) of human heart lysate (RIPA buffer, 30 µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O43184
Other Accession NP_067673, 8038
Reactivity Human
Host Goat
Clonality Polyclonal
Concentration 0.5 mg/ml
Isotype IgG
Calculated MW 99542 Da
Additional Information
Gene ID 8038
Other Names Disintegrin and metalloproteinase domain-containing protein 12, ADAM 12, 3.4.24.-, Meltrin-alpha, ADAM12, MLTN
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-ADAM12 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ADAM12
Synonyms MLTN
Function Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors (By similarity).
Cellular Location Isoform 1: Cell membrane; Single-pass type I membrane protein Isoform 3: Secreted.
Tissue Location Isoform 1 is expressed in placenta and skeletal, cardiac, and smooth muscle. Isoform 2 seems to be expressed only in placenta or in embryo and fetus. Both forms were expressed in some tumor cells lines. Not detected in brain, lung, liver, kidney or pancreas
Research Areas
Citations ( 0 )


This gene encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene has two alternatively spliced transcripts: a shorter secreted form and a longer membrane-bound form. The shorter form is found to stimulate myogenesis.


ADAM12 is an effective marker in the second trimester of pregnancy for prenatal screening of Down syndrome. Wang M, et al. Prenat Diagn, 2010 Jun. PMID 20509157. ADAM-12 stability in first trimester maternal serum. Cowans NJ, et al. Prenat Diagn, 2010 Jun. PMID 20509156. The role of SnoN in transforming growth factor beta1-induced expression of metalloprotease-disintegrin ADAM12. Solomon E, et al. J Biol Chem, 2010 Jul 16. PMID 20457602. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614. Reduced density of ADAM 12-immunoreactive oligodendrocytes in the anterior cingulate white matter of patients with schizophrenia. Farkas N, et al. World J Biol Psychiatry, 2010 Apr. PMID 20218926.

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$ 325.00
Cat# AF1025a
(40 western blots)
Availability: 7-10 days
Bulk Size
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