|Application ||WB, E|
|Other Accession||NP_079496, 80332|
|Calculated MW||87739 Da|
|Other Names||Disintegrin and metalloproteinase domain-containing protein 33, ADAM 33, 3.4.24.-, ADAM33, C20orf153|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-ADAM33 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed in all tissues, except liver, with high expression in placenta, lung, spleen and veins|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This protein is a type I transmembrane protein implicated in asthma and bronchial hyperresponsiveness. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.
Association of IL-4 and ADAM33 gene polymorphisms with asthma in an Indian population. Bijanzadeh M, et al. Lung, 2010 Oct. PMID 20524005.
Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. Schuurhof A, et al. Pediatr Pulmonol, 2010 Jun. PMID 20503287.
Association of ADAM33 polymorphisms and susceptibility to psoriasis. Deng W, et al. DNA Cell Biol, 2010 Aug. PMID 20491578.
Replication of genetic association studies in asthma and related phenotypes. Undarmaa S, et al. J Hum Genet, 2010 Jun. PMID 20395963.
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