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Goat Anti-ADRB3 Antibody
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P13945 |
| Other Accession | NP_000016, 155 |
| Reactivity | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 43519 Da |
| Gene ID | 155 |
|---|---|
| Other Names | Beta-3 adrenergic receptor, Beta-3 adrenoreceptor, Beta-3 adrenoceptor, ADRB3, ADRB3R, B3AR |
| Format | 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat Anti-ADRB3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ADRB3 |
|---|---|
| Synonyms | ADRB3R, B3AR |
| Function | Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta- 3 is involved in the regulation of lipolysis and thermogenesis. |
| Cellular Location | Cell membrane; Multi-pass membrane protein. |
| Tissue Location | Expressed mainly in adipose tissues. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene belongs to the family of beta adrenergic receptors, which mediate catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor is located mainly in the adipose tissue and is involved in the regulation of lipolysis and thermogenesis.
References
The Effects of Uncoupling Protein 1 and beta3-Adrenergic Receptor Gene Polymorphisms on Weight Loss and Lipid Profiles in Obese Women. Kim JY, et al. Int J Vitam Nutr Res, 2010 Mar. PMID 20803423.
Distribution of the Trp64Arg polymorphism in the beta(3)-adrenergic receptor gene in athletes and its influence on cardiovascular function. Kim SM, et al. Kardiol Pol, 2010 Aug. PMID 20730725.
Association between Genetic Polymorphisms of Adrenergic Receptor and Diurnal Intraocular Pressure in Japanese Normal-Tension Glaucoma. Gao Y, et al. Ophthalmology, 2010 Aug 10. PMID 20705341.
The Trp64Arg polymorphism of the beta3-adrenergic receptor gene is associated with weight changes in obese Japanese men: a 4-year follow-up study. Yamakita M, et al. J Physiol Anthropol, 2010. PMID 20686326.
Beta3-adrenergic receptor polymorphism is related to cardiometabolic risk factors in obese Brazilian subjects. Genelhu VA, et al. Genet Mol Res, 2010. PMID 20662153.
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