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AIRE (isoform 1) AntibodyPeptide-affinity purified goat antibody
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AF1041a | 0.1mg 400 ul | 7-10 days | $ 325.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
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AIRE (isoform 1) Antibody - Product info | |
| Other Accession | NP_000374 |
| Reactivity | Human |
| Concentration | 100ug/200ul |
| Isotype | IgG |
AIRE (isoform 1) Antibody - Additional info | |
| Other Names AIRE; autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy) ; AIRE1; APECED; APS1; APSI; PGA1 ; autoimmune regulator (APECED protein); autoimmune regulator (automimmune polyendocrinopathy candidiasis ectodermal dystrophy); autoimmune regulator AIRE | |
| Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions AIRE (isoform 1) Antibody is for research use only and not for use in diagnostic or therapeutic procedures. | |
AIRE (isoform 1) Antibody - Application data
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AF1041a staining (0.05 µg/ml) of HEK293 cell lysates. Untransfected (Lane 3) and transfected with Human AIRE (lane 4). Data kindly provided by Prof. PÃ €rt Peterson, University of Tartu, Estonia.
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AF1041a (2.5 µg/ml) staining of paraffin embedded Human Thymus. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
AIRE (isoform 1) Antibody - Related products
AP11079c: AIRE Antibody (Center)
AF1041a: AIRE (isoform 1) Antibody
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BACKGROUND
This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CBP. At least three splice variant mRNAs products have been described including one which results in a premature stop codon and a transcript predicted to be a candidate for nuclear-mediated decay (NMD). Defects in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).
REFERENCES
AIRE GENE MUTATIONS AND AUTOANTIBODIES TO INTERFERON OMEGA IN PATIENTS WITH CHRONIC HYPOPARATHYROIDISM WITHOUT APECED. Cervato S, et al. Clin Endocrinol (Oxf), 2010 Aug 13. PMID 20718774. Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? Rua帽o G, et al. Pharmacogenomics, 2010 Jul. PMID 20602615. The role of AIRE polymorphisms in melanoma. Conteduca G, et al. Clin Immunol, 2010 Jul. PMID 20363194. Aire regulates the expression of differentiation-associated genes and self-renewal of embryonic stem cells. Gu B, et al. Biochem Biophys Res Commun, 2010 Apr 2. PMID 20226168. Increased apoptosis after autoimmune regulator expression in epithelial cells revealed by a combined quantitative proteomics approach. Colom茅 N, et al. J Proteome Res, 2010 May 7. PMID 20218732.
