|Application ||WB, E|
|Other Accession||NP_006413, 10566|
|Predicted||Mouse, Rat, Pig, Dog, Cow|
|Calculated MW||94751 Da|
|Other Names||A-kinase anchor protein 3, AKAP-3, A-kinase anchor protein 110 kDa, AKAP 110, Cancer/testis antigen 82, CT82, Fibrous sheath protein of 95 kDa, FSP95, Fibrousheathin I, Fibrousheathin-1, Protein kinase A-anchoring protein 3, PRKA3, Sperm oocyte-binding protein, AKAP3, AKAP110, SOB1|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-AKAP3 / SOB1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May function as a regulator of both motility- and head- associated functions such as capacitation and the acrosome reaction.|
|Cellular Location||Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Ribs of the fibrous sheath in the principal piece of the sperm tail. Dorsal margin of the acrosomal segment|
|Tissue Location||Testis specific; only expressed in spermatids.|
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Provided below are standard protocols that you may find useful for product applications.
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family, and is expressed in testis only. The encoded protein contains an RII-binding domain, and is predicted to participate in protein-protein interactions with the R-subunit of the PKA. This protein is localized to the ribs of the fibrous sheath in the principal piece of the sperm tail. It may function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction.
Human spermatozoa contain multiple targets for protein S-nitrosylation: an alternative mechanism of the modulation of sperm function by nitric oxide? Lefi脷vre L, et al. Proteomics, 2007 Sep. PMID 17683036.
A-kinase anchoring protein 3 messenger RNA expression correlates with poor prognosis in epithelial ovarian cancer. Sharma S, et al. Gynecol Oncol, 2005 Oct. PMID 16005946.
Association of sperm protein 17 with A-kinase anchoring protein 3 in flagella. Lea IA, et al. Reprod Biol Endocrinol, 2004 Jul 16. PMID 15257753.
A-kinase anchoring protein 3 messenger RNA expression in ovarian cancer and its implication on prognosis. Hasegawa K, et al. Int J Cancer, 2004 Jan 1. PMID 14618620.
A-kinase anchoring protein 4 binding proteins in the fibrous sheath of the sperm flagellum. Brown PR, et al. Biol Reprod, 2003 Jun. PMID 12606363.
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