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Androgen Receptor AntibodyPeptide-affinity purified goat antibody
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AF1061a | 0.1mg 400 ul | 7-10 days | $ 325.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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Androgen Receptor Antibody - Product info | |
| Other Accession | NP_000035 |
| Reactivity | Human |
| Concentration | 100ug/200ul |
| Isotype | IgG |
Androgen Receptor Antibody - Additional info | |
| Other Names AR; androgen receptor; dihydrotestosterone receptor; KD; AIS; TFM; DHTR; SBMA; NR3C4; SMAX1; HUMARA; HYSP1; androgen receptor; dihydrotestosterone receptor; RP11-383C12.1 | |
| Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions Androgen Receptor Antibody is for research use only and not for use in diagnostic or therapeutic procedures. | |
Androgen Receptor Antibody - Application data
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AF1061a(0.3 µg/ml) staining of Human Brain lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Androgen Receptor Antibody - Related products
AP2509a: Androgen Receptor (ANDR) Antibody
AP10111c: AR Antibody (Center)
AP13058c: AR Antibody (Center)
AP13255c: AR Antibody (Center)
BP10111c: AR Antibody (Center) Blocking peptide
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Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described.
REFERENCES
Depressive Symptoms in Men Aged 50 Years and Older and Their Relationship to Genetic Androgen Receptor Polymorphism and Sex Hormone Levels in Three Different Samples. Schneider G, et al. Am J Geriatr Psychiatry, 2010 Jun 25. PMID 20808127. Germline study of AR gene of Indian women with ovarian failure. Panda B, et al. Gynecol Endocrinol, 2010 Jul 30. PMID 20672904. Bone mass and the CAG and GGN androgen receptor polymorphisms in young men. Guadalupe-Grau A, et al. PLoS One, 2010 Jul 12. PMID 20634949. Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolism and breast cancer risk in the NCI breast and prostate cancer cohort consortium. Canzian F, et al. Hum Mol Genet, 2010 Oct 1. PMID 20634197. Polymorphisms in the AR and PSA Genes as Markers of Susceptibility and Aggressiveness in Prostate Cancer. Kuasne H, et al. Cancer Invest, 2010 Jul 15. PMID 20632874.
