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APOB AntibodyPeptide-affinity purified goat antibody
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AF1076a | 0.1mg 400 ul | 7-10 days | $ 325.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
APOB Antibody - Product info | |
| Application | WB
|
| Other Accession | NP_000375 |
| Reactivity | Human |
| Concentration | 100ug/200ul |
| Isotype | IgG |
APOB Antibody - Additional info | |
| Other Names APOB; apolipoprotein B (including Ag(x) antigen); FLDB; apoB-100; apoB-48; apolipoprotein B; apolipoprotein B48 | |
| Dilution WB~~1:500~2000 | |
| Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions APOB Antibody is for research use only and not for use in diagnostic or therapeutic procedures. | |
APOB Antibody - Application data
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AF1076a (0.5 µg/ml) staining of Human Serum lysates. Data kindly provided by Yan Xie and NO Davidson, Washington USA. This antibody showed background below 150kDa in serum samples . We call for caution when used for other assays than Western blot.
APOB Antibody - Related products
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BACKGROUND
This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective apoB, diseases affecting plasma cholesterol and apoB levels.
REFERENCES
ApoB genetic variants modify the response to fenofibrate: a GOLDN study. Wojczynski MK, et al. J Lipid Res, 2010 Aug 19. PMID 20724655. Pharmacogenetic analysis of lipid responses to rosuvastatin in Chinese patients. Hu M, et al. Pharmacogenet Genomics, 2010 Oct. PMID 20679960. A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM). Romero R, et al. Am J Obstet Gynecol, 2010 Jul 29. PMID 20673868. Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia. Johansen CT, et al. Nat Genet, 2010 Aug. PMID 20657596. [Distribution characteristics of ApoB3'VNTR and hyperlipemia correlation factors in civil aircrew] Zhu F, et al. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi, 2010 Mar. PMID 20635694.
