|Application ||WB, IHC, E|
|Other Accession||NP_000032, 348|
|Calculated MW||36154 Da|
|Other Names||Apolipoprotein E, Apo-E, APOE|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-APOE Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.|
|Tissue Location||Occurs in all lipoprotein fractions in plasma. It constitutes 10-20% of very low density lipoproteins (VLDL) and 1-2% of high density lipoproteins (HDL). APOE is produced in most organs. Significant quantities are produced in liver, brain, spleen, lung, adrenal, ovary, kidney and muscle|
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Provided below are standard protocols that you may find useful for product applications.
Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.
Isoform of APOE with retained intron 3; quantitation and identification of an associated single nucleotide polymorphism. Dieter LS, et al. Mol Neurodegener, 2010 Sep 7. PMID 20822524.
The APOE varepsilon4 allele modulates brain white matter integrity in healthy adults. Heise V, et al. Mol Psychiatry, 2010 Sep 7. PMID 20820167.
Prevalence of mild cognitive impairment is higher in men. The Mayo Clinic Study of Aging. Petersen RC, et al. Neurology, 2010 Sep 7. PMID 20820000.
Testosterone modifies the effect of APOE genotype on hippocampal volume in middle-aged men. Panizzon MS, et al. Neurology, 2010 Sep 7. PMID 20819998.
Polymorphisms in Glutathione S-Transferase Omega-1 Gene and Increased Risk of Sporadic Alzheimer Disease. Capurso C, et al. Rejuvenation Res, 2010 Sep 6. PMID 20818931.
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