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AREB6 / ZEB1 AntibodyPeptide-affinity purified goat antibody
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AF1093a | 0.1mg 400 ul | 7-10 days | $ 325.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
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- Backgrounds
AREB6 / ZEB1 Antibody - Product info | |
| Other Accession | NP_110378 |
| Reactivity | Human, Mouse |
| Concentration | 100ug/200ul |
| Isotype | IgG |
AREB6 / ZEB1 Antibody - Additional info | |
| Other Names ZEB1; AREB6; zinc finger E-box binding homeobox 1; BZP; DELTA-EF1; MGC133261; NIL-2-A; NIL-2A; NIL2A; TCF8; ZEB; ZFHEP; ZFHX1A; OTTHUMP00000019405; transcription factor 8 (represses interleukin 2 expression); zinc finger homeodomain enhancer-binding protein | |
| Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions AREB6 / ZEB1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. | |
AREB6 / ZEB1 Antibody - Application data
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AF1093a (0.05 µg/ml) staining of Mouse Heart lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
AREB6 / ZEB1 Antibody - Related products
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BACKGROUND
This gene encodes a zinc finger transcription factor. The encoded protein likely plays a role in transcriptional repression of interleukin 2. Mutations in this gene have been associated with posterior polymorphous corneal dystrophy-3 and late-onset Fuchs endothelial corneal dystrophy. Alternatively spliced transcript variants encoding different isoforms have been described.
REFERENCES
Downregulation of ZEB1 and overexpression of Smad7 contribute to resistance to TGF-beta1-mediated growth suppression in adult T-cell leukemia/lymphoma. Nakahata S, et al. Oncogene, 2010 Jul 22. PMID 20514018. Knockdown of ZEB1, a master epithelial-to-mesenchymal transition (EMT) gene, suppresses anchorage-independent cell growth of lung cancer cells. Takeyama Y, et al. Cancer Lett, 2010 Oct 28. PMID 20452118. Epidermal growth factor receptor and mutant p53 expand an esophageal cellular subpopulation capable of epithelial-to-mesenchymal transition through ZEB transcription factors. Ohashi S, et al. Cancer Res, 2010 May 15. PMID 20424117. ZEB1 represses E-cadherin and induces an EMT by recruiting the SWI/SNF chromatin-remodeling protein BRG1. S谩nchez-Till贸 E, et al. Oncogene, 2010 Jun 17. PMID 20418909. Either ZEB1 or ZEB2/SIP1 can play a central role in regulating the Epstein-Barr virus latent-lytic switch in a cell-type-specific manner. Ellis AL, et al. J Virol, 2010 Jun. PMID 20375168.
