|Application ||WB, IHC, IF, IP, E|
|Other Accession||NP_446464, 445, 11898 (mouse), 25698 (rat)|
|Calculated MW||46530 Da|
|Other Names||Argininosuccinate synthase, 126.96.36.199, Citrulline--aspartate ligase, ASS1, ASS|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-Argininosuccinate synthetase 1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Is indirectly involved in the control of blood pressure.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene catalyzes the penultimate step of the arginine biosynthetic pathway. There are approximately 10 to 14 copies of this gene including the pseudogenes scattered across the human genome, among which the one located on chromosome 9 appears to be the only functional gene for argininosuccinate synthetase. Mutations in the chromosome 9 copy of ASS cause citrullinemia. Two transcript variants encoding the same protein have been found for this gene.
Polymorphic variants of genes related to arginine metabolism and the risk of orofacial clefts. Hozyasz KK, et al. Arch Oral Biol, 2010 Aug 23. PMID 20739017.
Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.
Reduced argininosuccinate synthetase is a predictive biomarker for the development of pulmonary metastasis in patients with osteosarcoma. Kobayashi E, et al. Mol Cancer Ther, 2010 Mar. PMID 20159990.
Resistance to arginine deiminase treatment in melanoma cells is associated with induced argininosuccinate synthetase expression involving c-Myc/HIF-1alpha/Sp4. Tsai WB, et al. Mol Cancer Ther, 2009 Dec. PMID 19934275.
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. Talmud PJ, et al. Am J Hum Genet, 2009 Nov. PMID 19913121.
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