|Application ||WB, E|
|Other Accession||NP_000478, 410, 11883 (mouse), 315222 (rat)|
|Calculated MW||53588 Da|
|Other Names||Arylsulfatase A, ASA, 188.8.131.52, Cerebroside-sulfatase, Arylsulfatase A component B, Arylsulfatase A component C, ARSA|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-Arylsulfatase A Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Hydrolyzes cerebroside sulfate.|
|Cellular Location||Endoplasmic reticulum. Lysosome|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene hydrolyzes cerebroside sulfate to cerebroside and sulfate. Defects in this gene lead to metachromatic leucodystrophy (MLD), a progressive demyelination disease which results in a variety of neurological symptoms and ultimately death. Multiple alternatively spliced transcript variants, one of which encodes a distinct protein, have been described for this gene.
Characterization of new arylsulfatase A gene mutations reinforces genotype-phenotype correlation in metachromatic leukodystrophy. Cesani M, et al. Hum Mutat, 2009 Oct. PMID 19606494.
Characterization of the arylsulfatase I (ARSI) gene preferentially expressed in the human retinal pigment epithelium cell line ARPE-19. Oshikawa M, et al. Mol Vis, 2009. PMID 19262745.
Saposin B-dependent reconstitution of arylsulfatase A activity in vitro and in cell culture models of metachromatic leukodystrophy. Matzner U, et al. J Biol Chem, 2009 Apr 3. PMID 19224915.
Chromosomal deletion unmasking a recessive disease: 22q13 deletion syndrome and metachromatic leukodystrophy. Bisgaard AM, et al. Clin Genet, 2009 Feb. PMID 19054018.
Molecular and clinical consequences of novel mutations in the arylsulfatase A gene. 艁ugowska A, et al. Clin Genet, 2009 Jan. PMID 19021637.
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