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Goat Anti-ASNA1 Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-ASNA1 Antibody AF1119c
    AF1119c (1 µg/ml) staining of Mouse Kidney lysate (35 µg protein in RIPA buffer) with (B) and without (A) blocking with the immunising peptide. Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O43681
Other Accession NP_004308, 439
Reactivity Human, Mouse, Rat
Predicted Cow
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 38793 Da
Additional Information
Gene ID 439
Other Names ATPase ASNA1 {ECO:0000255|HAMAP-Rule:MF_03112}, 3.6.-.- {ECO:0000255|HAMAP-Rule:MF_03112}, Arsenical pump-driving ATPase {ECO:0000255|HAMAP-Rule:MF_03112}, Arsenite-stimulated ATPase {ECO:0000255|HAMAP-Rule:MF_03112}, Transmembrane domain recognition complex 40 kDa ATPase subunit, hARSA-I, hASNA-I, ASNA1 {ECO:0000255|HAMAP-Rule:MF_03112}, ARSA, TRC40
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-ASNA1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ASNA1 {ECO:0000255|HAMAP-Rule:MF_03112}
Synonyms ARSA, TRC40
Function ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail- anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting (By similarity). May be involved in insulin signaling.
Cellular Location Cytoplasm. Endoplasmic reticulum. Nucleus, nucleolus
Tissue Location Expressed in the epithelial cells of the liver, kidney, and stomach wall, in the adrenal medulla, in the islet cells of the pancreas, in the red pulp of the spleen, and in cardiac and skeletal muscle.
Research Areas
Citations (0)

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ASNA1 is the human homolog of the bacterial arsA gene. In E. coli, ArsA ATPase is the catalytic component of a multisubunit oxyanion pump that is responsible for resistance to arsenicals and antimonials.


Asna1/TRC40-mediated membrane insertion of tail-anchored proteins. Favaloro V, et al. J Cell Sci, 2010 May 1. PMID 20375064.
Increased sensitivity to platinating agents and arsenite in human ovarian cancer by downregulation of ASNA1. Hemmingsson O, et al. Oncol Rep, 2009 Oct. PMID 19724867.
Defining the human deubiquitinating enzyme interaction landscape. Sowa ME, et al. Cell, 2009 Jul 23. PMID 19615732.
A precursor-specific role for Hsp40/Hsc70 during tail-anchored protein integration at the endoplasmic reticulum. Rabu C, et al. J Biol Chem, 2008 Oct 10. PMID 18667436.
Identification of a targeting factor for posttranslational membrane protein insertion into the ER. Stefanovic S, et al. Cell, 2007 Mar 23. PMID 17382883.

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$ 325.00
Cat# AF1119c
(40 western blots)
Availability: 7-10 days
Bulk Size
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