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Goat Anti-ASNA1 Antibody
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O43681 |
| Other Accession | NP_004308, 439 |
| Reactivity | Human, Mouse, Rat |
| Predicted | Cow |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 100ug/200ul |
| Isotype | IgG |
| Calculated MW | 38793 Da |
| Gene ID | 439 |
|---|---|
| Other Names | ATPase ASNA1 {ECO:0000255|HAMAP-Rule:MF_03112}, 3.6.-.- {ECO:0000255|HAMAP-Rule:MF_03112}, Arsenical pump-driving ATPase {ECO:0000255|HAMAP-Rule:MF_03112}, Arsenite-stimulated ATPase {ECO:0000255|HAMAP-Rule:MF_03112}, Transmembrane domain recognition complex 40 kDa ATPase subunit, hARSA-I, hASNA-I, ASNA1 {ECO:0000255|HAMAP-Rule:MF_03112}, ARSA, TRC40 |
| Format | 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat Anti-ASNA1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GET3 {ECO:0000255|HAMAP-Rule:MF_03112, ECO:0000312|HGNC:HGNC:752} |
|---|---|
| Function | ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors GET1/WRB and CAMLG/GET2, where the tail- anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the GET1-CAMLG receptor, and returning it to the cytosol to initiate a new round of targeting. May be involved in insulin signaling. |
| Cellular Location | Cytoplasm. Endoplasmic reticulum. Nucleus, nucleolus |
| Tissue Location | Expressed in the epithelial cells of the liver, kidney, and stomach wall, in the adrenal medulla, in the islet cells of the pancreas, in the red pulp of the spleen, and in cardiac and skeletal muscle. |
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Provided below are standard protocols that you may find useful for product applications.
Background
ASNA1 is the human homolog of the bacterial arsA gene. In E. coli, ArsA ATPase is the catalytic component of a multisubunit oxyanion pump that is responsible for resistance to arsenicals and antimonials.
References
Asna1/TRC40-mediated membrane insertion of tail-anchored proteins. Favaloro V, et al. J Cell Sci, 2010 May 1. PMID 20375064.
Increased sensitivity to platinating agents and arsenite in human ovarian cancer by downregulation of ASNA1. Hemmingsson O, et al. Oncol Rep, 2009 Oct. PMID 19724867.
Defining the human deubiquitinating enzyme interaction landscape. Sowa ME, et al. Cell, 2009 Jul 23. PMID 19615732.
A precursor-specific role for Hsp40/Hsc70 during tail-anchored protein integration at the endoplasmic reticulum. Rabu C, et al. J Biol Chem, 2008 Oct 10. PMID 18667436.
Identification of a targeting factor for posttranslational membrane protein insertion into the ER. Stefanovic S, et al. Cell, 2007 Mar 23. PMID 17382883.
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