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Asporin / ASPN AntibodyPeptide-affinity purified goat antibody
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AF1120a | 0.1mg 400 ul | 7-10 days | $ 325.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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Asporin / ASPN Antibody - Product info | |
| Other Accession | NP_060150 |
| Reactivity | Human, Mouse |
| Concentration | 100ug/200ul |
| Isotype | IgG |
Asporin / ASPN Antibody - Additional info | |
| Other Names ASPN; PLAP1; SLRR1C; FLJ20129; asporin (LRR class 1); small leucine-rich protein 1C; periodontal ligament associated protein 1; asporin; OS3; asporin proteoglycan | |
| Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions Asporin / ASPN Antibody is for research use only and not for use in diagnostic or therapeutic procedures. | |
Asporin / ASPN Antibody - Application data
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AF1120a (0.3 µg/ml) staining of Human Bone Marrow lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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AF1120a staining of ATDC5 cells (Panels A and C) and DAPI (panels B and D). Data gratefully received from Dr. Shiro Ikegawa, SNP Research Center, RIKEN, Japan.
Asporin / ASPN Antibody - Related products
AP6604c: ASPN Antibody (Center)
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BACKGROUND
This gene encodes a cartilage extracellular protein that is member of the small leucine-rich proteoglycan family. The encoded protein may regulate chondrogenesis by inhibiting transforming growth factor-beta 1-induced gene expression in cartilage. This protein also binds collagen and calcium and may induce collagen mineralization. Polymorphisms in the aspartic acid repeat region of this gene are associated with a susceptibility to osteoarthritis. Alternate splicing results in multiple transcript variants.
REFERENCES
Association of an asporin repeat polymorphism with ankylosing spondylitis in Han Chinese population: a case-control study. Liu D, et al. Clin Invest Med, 2010 Feb 1. PMID 20144272. Asporin and transforming growth factor-beta gene expression in osteoblasts from subchondral bone and osteophytes in osteoarthritis. Sakao K, et al. J Orthop Sci, 2009 Nov. PMID 19997821. Asporin competes with decorin for collagen binding, binds calcium and promotes osteoblast collagen mineralization. Kalamajski S, et al. Biochem J, 2009 Sep 14. PMID 19589127. Asporin, a susceptibility gene in osteoarthritis, is expressed at higher levels in the more degenerate human intervertebral disc. Gruber HE, et al. Arthritis Res Ther, 2009. PMID 19327154. Association of the CALM1 core promoter polymorphism with knee osteoarthritis in patients of Greek origin. Poulou M, et al. Genet Test, 2008 Jun. PMID 18452398.
