Goat Anti-B3GNT2 Antibody
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q9NY97 |
Other Accession | NP_006568, 10678, 53625 (mouse) |
Reactivity | Human |
Predicted | Mouse, Rat |
Host | Goat |
Clonality | Polyclonal |
Concentration | 100ug/200ul |
Isotype | IgG |
Calculated MW | 46022 Da |
Gene ID | 10678 |
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Other Names | N-acetyllactosaminide beta-1, 3-N-acetylglucosaminyltransferase 2, 2.4.1.149, Beta-1, 3-N-acetylglucosaminyltransferase 1, BGnT-1, Beta-1, 3-Gn-T1, Beta3Gn-T1, Beta-1, 3-galactosyltransferase 7, Beta-1, 3-GalTase 7, Beta3Gal-T7, Beta3GalT7, b3Gal-T7, Beta-3-Gx-T7, UDP-Gal:beta-GlcNAc beta-1, 3-galactosyltransferase 7, UDP-GlcNAc:betaGal beta-1, 3-N-acetylglucosaminyltransferase 2, BGnT-2, Beta-1, 3-Gn-T2, Beta-1, 3-N-acetylglucosaminyltransferase 2, Beta3Gn-T2, UDP-galactose:beta-N-acetylglucosamine beta-1, 3-galactosyltransferase 7, B3GNT2, B3GALT7, B3GNT1 |
Format | 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | Goat Anti-B3GNT2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | B3GNT2 |
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Synonyms | B3GALT7, B3GNT1 |
Function | Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Catalyzes the initiation and elongation of poly-N-acetyllactosamine chains. Shows a marked preference for Gal(beta1-4)Glc(NAc)-based acceptors (PubMed:9892646). Probably constitutes the main polylactosamine synthase. |
Cellular Location | Golgi apparatus membrane; Single- pass type II membrane protein |
Tissue Location | Ubiquitous.. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II transmembrane protein. It prefers the substrate of lacto-N-neotetraose, and is involved in the biosynthesis of poly-N-acetyllactosamine chains.
References
Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci. Australo-Anglo-American Spondyloarthritis Consortium (TASC), et al. Nat Genet, 2010 Feb. PMID 20062062.
Activation of beta1,3-N-acetylglucosaminyltransferase-2 (beta3Gn-T2) by beta3Gn-T8. Possible involvement of beta3Gn-T8 in increasing poly-N-acetyllactosamine chains in differentiated HL-60 cells. Seko A, et al. J Biol Chem, 2008 Nov 28. PMID 18826941.
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. Liu T, et al. J Proteome Res, 2005 Nov-Dec. PMID 16335952.
Characterization of a cDNA encoding a protein with limited similarity to beta1, 3-N-acetylglucosaminyltransferase. Zheng H, et al. Mol Biol Rep, 2004 Sep. PMID 15560372.
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.
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