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Goat Anti-B56 beta isoform Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-B56 beta isoform Antibody AF1133a
    AF1133a (2 µg/ml) staining of Human Cerebellum lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q15173
Other Accession NP_006235, 5526
Reactivity Human
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 57393 Da
Additional Information
Gene ID 5526
Other Names Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform, PP2A B subunit isoform B'-beta, PP2A B subunit isoform B56-beta, PP2A B subunit isoform PR61-beta, PP2A B subunit isoform R5-beta, PPP2R5B
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-B56 beta isoform Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PPP2R5B
Function The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The phosphorylated form mediates the interaction between AKT1 and PP2A phosphatase leading to dephosphorylation of AKT1 on the 'Thr-308' and 'Ser-373' residues.
Cellular Location Cytoplasm.
Tissue Location Highest expression in brain.
Research Areas
Citations (0)

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The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B56 subfamily.


A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein. Goudreault M, et al. Mol Cell Proteomics, 2009 Jan. PMID 18782753.
B56beta, a regulatory subunit of protein phosphatase 2A, interacts with CALEB/NGC and inhibits CALEB/NGC-mediated dendritic branching. Brandt N, et al. FASEB J, 2008 Jul. PMID 18385213.
Shugoshin collaborates with protein phosphatase 2A to protect cohesin. Kitajima TS, et al. Nature, 2006 May 4. PMID 16541025.
Protein phosphatase 2A protects centromeric sister chromatid cohesion during meiosis I. Riedel CG, et al. Nature, 2006 May 4. PMID 16541024.
B56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX-1 and ERK. Letourneux C, et al. EMBO J, 2006 Feb 22. PMID 16456541.

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$ 325.00
Cat# AF1133a
(40 western blots)
Availability: 7-10 days
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