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Goat Anti-B7-H4 Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-B7-H4 Antibody AF1134a
    AF1134a (0.5 µg/ml) staining of Human Pancreas lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q7Z7D3
Other Accession NP_078902, 79679, 242122 (mouse), 295322 (rat)
Reactivity Human
Predicted Mouse, Rat, Dog
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 30878 Da
Additional Information
Gene ID 79679
Other Names V-set domain-containing T-cell activation inhibitor 1, B7 homolog 4, B7-H4, B7h.5, Immune costimulatory protein B7-H4, Protein B7S1, T-cell costimulatory molecule B7x, VTCN1 {ECO:0000312|EMBL:EAW56672.1}
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-B7-H4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name VTCN1 {ECO:0000312|EMBL:EAW56672.1}
Function Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor- associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.
Cellular Location Cell membrane; Single-pass type I membrane protein. Note=Expressed at the cell surface. A soluble form has also been detected. {ECO:0000255, ECO:0000269|PubMed:12818165, ECO:0000269|PubMed:15878339, ECO:0000269|PubMed:16782226}
Tissue Location Overexpressed in breast, ovarian, endometrial, renal cell (RCC) and non-small-cell lung cancers (NSCLC) Expressed on activated T- and B-cells, monocytes and dendritic cells, but not expressed in most normal tissues (at protein level). Widely expressed, including in kidney, liver, lung, ovary, placenta, spleen and testis.
Research Areas
Citations (0)

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B7H4 belongs to the B7 family (see CD80; MIM 112203) of costimulatory proteins. These proteins are expressed on the surface of antigen-presenting cells and interact with ligands (e.g., CD28; MIM 186760) on T lymphocytes.


B7-H4 expression promotes tumorigenesis in ovarian cancer. Cheng L, et al. Int J Gynecol Cancer, 2009 Dec. PMID 19955922.
B7-H4 gene polymorphisms are associated with sporadic breast cancer in a Chinese Han population. Zhang J, et al. BMC Cancer, 2009 Nov 11. PMID 19903360.
The negative co-signaling molecule b7-h4 is expressed by human bone marrow-derived mesenchymal stem cells and mediates its T-cell modulatory activity. Xue Q, et al. Stem Cells Dev, 2010 Jan. PMID 19788399.
Identification of a novel susceptibility locus for juvenile idiopathic arthritis by genome-wide association analysis. Hinks A, et al. Arthritis Rheum, 2009 Jan. PMID 19116933.
Serum-soluble B7x is elevated in renal cell carcinoma patients and is associated with advanced stage. Thompson RH, et al. Cancer Res, 2008 Aug 1. PMID 18676826.

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$ 325.00
Cat# AF1134a
(40 western blots)
Availability: 7-10 days
Bulk Size
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