|Application ||WB, E|
|Other Accession||NP_079088, 79870, 118452 (mouse), 140720 (rat)|
|Calculated MW||19224 Da|
|Other Names||Brain and acute leukemia cytoplasmic protein, BAALC|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-BAALC Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May play a synaptic role at the postsynaptic lipid rafts by interacting with CAMK2A.|
|Cellular Location||Cytoplasm. Membrane. Note=Postsynaptic lipid rafts.|
|Tissue Location||Expressed by neural and hematopoietic cells. Expression is found both in normal early progenitor cells and in the most immature type of blasts in acute leukemia but not in mature hematopoietic cells. Isoform 2 and isoform 6 are expressed in the brain. Isoform 2 shows a low expression in neuroectoderm- derived tissues such as adrenal gland and no expression in bone marrow, peripheral blood lymphocytes or lymph nodes, or in tumors or cancer cell lines of nonneural tissue origin|
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Provided below are standard protocols that you may find useful for product applications.
This gene was identified by gene expression studies in patients with acute myeloid leukemia (AML). The gene is conserved among mammals and is not found in lower organisms. Tissues that express this gene develop from the neuroectoderm. Multiple alternatively spliced transcript variants that encode different proteins have been described for this gene; however, some of the transcript variants are found only in AML cell lines.
BAALC-associated gene expression profiles define IGFBP7 as a novel molecular marker in acute leukemia. Heesch S, et al. Leukemia, 2010 Aug. PMID 20535151.
Prognostic significance of CEBPA mutations and BAALC expression in acute myeloid leukemia Egyptian patients with normal karyotype. El-Sharnouby JA, et al. Egypt J Immunol, 2008. PMID 20306678.
High BAALC expression predicts chemoresistance in adult B-precursor acute lymphoblastic leukemia. K脤hnl A, et al. Blood, 2010 May 6. PMID 20065290.
BAALC is an important predictor of refractoriness to chemotherapy and poor survival in intermediate-risk acute myeloid leukemia (AML). Santamar铆a C, et al. Ann Hematol, 2010 May. PMID 19943049.
BAALC and ERG expression in acute myeloid leukemia with normal karyotype: impact on prognosis. Eid MA, et al. Int J Lab Hematol, 2010 Apr. PMID 19555438.
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