|Application ||WB, E|
|Other Accession||NP_150594, 10612, 55992 (mouse), 83616 (rat)|
|Predicted||Human, Rat, Dog, Cow|
|Calculated MW||80830 Da|
|Other Names||Tripartite motif-containing protein 3, Brain-expressed RING finger protein, RING finger protein 22, RING finger protein 97, TRIM3, BERP, RNF22, RNF97|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-BERP / RNF22 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||BERP, RNF22, RNF97|
|Function||Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation.|
|Cellular Location||Cytoplasm. Early endosome|
|Tissue Location||Expressed in brain, heart, uterus and testis.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also called the 'RING-B-box-coiled-coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic filaments. It is similar to a rat protein which is a specific partner for the tail domain of myosin V, a class of myosins which are involved in the targeted transport of organelles. The rat protein can also interact with alpha-actinin-4. Thus it is suggested that this human protein may play a role in myosin V-mediated cargo transport. Alternatively spliced transcript variants encoding the same isoform have been identified.
Identification of BERP (brain-expressed RING finger protein) as a p53 target gene that modulates seizure susceptibility through interacting with GABA(A) receptors. Cheung CC, et al. Proc Natl Acad Sci U S A, 2010 Jun 29. PMID 20543135.
Glucocorticoid-induced gene tripartite motif-containing 63 (TRIM63) promotes differentiation of osteoblastic cells. Azuma K, et al. Endocr J, 2010. PMID 20173306.
Monoubiquitinylation regulates endosomal localization of Lst2, a negative regulator of EGF receptor signaling. Mosesson Y, et al. Dev Cell, 2009 May. PMID 19460345.
Loss of heterozygosity of TRIM3 in malignant gliomas. Boulay JL, et al. BMC Cancer, 2009 Feb 27. PMID 19250537.
Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia. Martins-de-Souza D, et al. Eur Arch Psychiatry Clin Neurosci, 2009 Apr. PMID 19165527.
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