|Application ||WB, IHC, E|
|Other Accession||NP_001704, 635, 12116 (mouse), 81508 (rat)|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||44998 Da|
|Other Names||Betaine--homocysteine S-methyltransferase 1, 18.104.22.168, BHMT|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-BHMT Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline.|
|Tissue Location||Found exclusively in liver and kidney.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a cytosolic enzyme that catalyzes the conversion of betaine and homocysteine to dimethylglycine and methionine, respectively. Defects in this gene could lead to hyperhomocyst(e)inemia, but such a defect has not yet been observed.
Maternal folate-related gene environment interactions and congenital heart defects. Hobbs CA, et al. Obstet Gynecol, 2010 Aug. PMID 20664391.
Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. Jugessur A, et al. PLoS One, 2010 Jul 9. PMID 20634891.
Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.
Early-onset ischaemic stroke: analysis of 58 polymorphisms in 17 genes involved in methionine metabolism. Giusti B, et al. Thromb Haemost, 2010 Aug 2. PMID 20458436.
A Large-scale genetic association study of esophageal adenocarcinoma risk. Liu CY, et al. Carcinogenesis, 2010 Jul. PMID 20453000.
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