|Application ||WB, E|
|Other Accession||NP_647601, 274, 30948 (mouse), 117028 (rat)|
|Predicted||Mouse, Rat, Pig, Dog, Cow|
|Calculated MW||64699 Da|
|Other Names||Myc box-dependent-interacting protein 1, Amphiphysin II, Amphiphysin-like protein, Box-dependent myc-interacting protein 1, Bridging integrator 1, BIN1, AMPHL|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-BIN1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in regulation of synaptic vesicle endocytosis. May act as a tumor suppressor and inhibits malignant cell transformation.|
|Cellular Location||Isoform BIN1: Nucleus.|
|Tissue Location||Ubiquitous. Highest expression in the brain and muscle. Isoform IIA is expressed only in the brain where it is concentrated in axon initial segments and nodes of Ranvier Isoform BIN1 is widely expressed with highest expression in skeletal muscle.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynanim, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.
Genetic variation and neuroimaging measures in Alzheimer disease. Biffi A, et al. Arch Neurol, 2010 Jun. PMID 20558387.
Genome-wide analysis of genetic loci associated with Alzheimer disease. Seshadri S, et al. JAMA, 2010 May 12. PMID 20460622.
Association of genetic variants with hemorrhagic stroke in Japanese individuals. Yoshida T, et al. Int J Mol Med, 2010 Apr. PMID 20198315.
BIN1 localizes the L-type calcium channel to cardiac T-tubules. Hong TT, et al. PLoS Biol, 2010 Feb 16. PMID 20169111.
Phenotype of a patient with recessive centronuclear myopathy and a novel BIN1 mutation. Claeys KG, et al. Neurology, 2010 Feb 9. PMID 20142620.
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.