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Goat Anti-Bin3 Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-Bin3 Antibody AF1156a
    AF1156a (0.3 µg/ml) staining of K562 lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q7L2J0
Other Accession NP_062552, 56257
Reactivity Human
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 74355 Da
Additional Information
Gene ID 56257
Other Names 7SK snRNA methylphosphate capping enzyme, MePCE, 2.1.1.-, Bicoid-interacting protein 3 homolog, Bin3 homolog, MEPCE, BCDIN3
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-Bin3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms BCDIN3
Function S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA, leading to stabilize it.
Tissue Location Expressed in chronic myeloid leukemia cells, adrenal gland, brain, cerebellum, kidney, lung, mammary gland and testis. Weakly or not expressed in other tissues
Research Areas
Citations (0)

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A capping-independent function of MePCE in stabilizing 7SK snRNA and facilitating the assembly of 7SK snRNP. Xue Y, et al. Nucleic Acids Res, 2010 Jan. PMID 19906723.
Defining the human deubiquitinating enzyme interaction landscape. Sowa ME, et al. Cell, 2009 Jul 23. PMID 19615732.
LARP7 is a stable component of the 7SK snRNP while P-TEFb, HEXIM1 and hnRNP A1 are reversibly associated. Krueger BJ, et al. Nucleic Acids Res, 2008 Apr. PMID 18281698.
Human capping enzyme promotes formation of transcriptional R loops in vitro. Kaneko S, et al. Proc Natl Acad Sci U S A, 2007 Nov 6. PMID 17978174.
Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. Jeronimo C, et al. Mol Cell, 2007 Jul 20. PMID 17643375.

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$ 325.00
Cat# AF1156a
(40 western blots)
Availability: 7-10 days
Bulk Size
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