|Application ||WB, E|
|Other Accession||NP_002457, 4605, 17865 (mouse), 296344 (rat)|
|Predicted||Human, Mouse, Pig, Dog, Cow|
|Calculated MW||78764 Da|
|Other Names||Myb-related protein B, B-Myb, Myb-like protein 2, MYBL2, BMYB|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-BMYB / MYBL2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Transcript variants may exist for this gene, but their full-length natures have not been determined.
Focal amplifications are associated with high grade and recurrences in stage Ta bladder carcinoma. Nord H, et al. Int J Cancer, 2010 Mar 15. PMID 19821490.
Genetic susceptibility to distinct bladder cancer subphenotypes. Guey LT, et al. Eur Urol, 2010 Feb. PMID 19692168.
PTEN identified as important risk factor of chronic obstructive pulmonary disease. Hosgood HD 3rd, et al. Respir Med, 2009 Dec. PMID 19625176.
B-MYB is required for recovery from the DNA damage-induced G2 checkpoint in p53 mutant cells. Mannefeld M, et al. Cancer Res, 2009 May 1. PMID 19383908.
Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. Shen M, et al. Environ Mol Mutagen, 2009 May. PMID 19170196.
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