|Application ||WB, E|
|Other Accession||NP_150279, 91653, 117606 (mouse)|
|Predicted||Mouse, Dog, Cow|
|Calculated MW||121059 Da|
|Other Names||Brother of CDO, Protein BOC, BOC|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-BOC Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein Note=Enriched at sites of cell-cell contact|
|Tissue Location||Detected in skeletal muscle, heart, thymus, kidney and small intestine. Detected at lower levels in brain, placenta, lung and colon mucosa.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
CDON (MIM 608707) and BOC are cell surface receptors of the immunoglobulin (Ig)/fibronectin type III (FNIII; see MIM 135600) repeat family involved in myogenic differentiation. CDON and BOC are coexpressed during development, form complexes with each other in a cis fashion, and are related to each other in their ectodomains, but each has a unique long cytoplasmic tail.
A Three-Stage Genome-Wide Association Study of General Cognitive Ability: Hunting the Small Effects. Davis OS, et al. Behav Genet, 2010 Mar 21. PMID 20306291.
Segregation of ipsilateral retinal ganglion cell axons at the optic chiasm requires the Shh receptor Boc. Fabre PJ, et al. J Neurosci, 2010 Jan 6. PMID 20053908.
The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice. Tenzen T, et al. Dev Cell, 2006 May. PMID 16647304.
A human protein-protein interaction network: a resource for annotating the proteome. Stelzl U, et al. Cell, 2005 Sep 23. PMID 16169070.
Netrins and neogenin promote myotube formation. Kang JS, et al. J Cell Biol, 2004 Nov 8. PMID 15520228.
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