|Application ||WB, E|
|Other Accession||NP_001078826, 151888, 208154 (mouse), 407756 (rat)|
|Calculated MW||32834 Da|
|Other Names||B- and T-lymphocyte attenuator, B- and T-lymphocyte-associated protein, CD272, BTLA|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-BTLA Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Lymphocyte inhibitory receptor which inhibits lymphocytes during immune response.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
BTLA expression is induced during activation of T cells, and BTLA remains expressed on Th1 cells but not Th2 cells. Like PD1 (MIM 600244) and CTLA4 (MIM 123890), BTLA interacts with a B7 homolog, B7H4.
Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. Mosbruger TL, et al. J Infect Dis, 2010 May 1. PMID 20331378.
PD1 as a common candidate susceptibility gene of subacute sclerosing panencephalitis. Ishizaki Y, et al. Hum Genet, 2010 Jan 12. PMID 20066438.
T cell intrinsic heterodimeric complexes between HVEM and BTLA determine receptivity to the surrounding microenvironment. Cheung TC, et al. J Immunol, 2009 Dec 1. PMID 19915044.
High expression of the inhibitory receptor BTLA in T-follicular helper cells and in B-cell small lymphocytic lymphoma/chronic lymphocytic leukemia. M'Hidi H, et al. Am J Clin Pathol, 2009 Oct. PMID 19762537.
Association of BTLA gene polymorphisms with the risk of malignant breast cancer in Chinese women of Heilongjiang Province. Fu Z, et al. Breast Cancer Res Treat, 2010 Feb. PMID 19585237.
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