|Application ||WB, E|
|Other Accession||NP_004267, 9478|
|Calculated MW||39838 Da|
|Other Names||Calcium-binding protein 1, CaBP1, Calbrain, Caldendrin, CABP1|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-CABP1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Modulates calcium-dependent activity of inositol 1,4,5- triphosphate receptors (ITPRs). Inhibits agonist-induced intracellular calcium signaling. Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels. Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but resulting in an opposit effects on channel function. Suppresses the calcium-dependent inactivation of CACNA1D (By similarity). Inhibits TRPC5 channels. Prevents NMDA receptor- induced cellular degeneration (By similarity).|
|Cellular Location||Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Cell membrane; Lipid-anchor; Cytoplasmic side Golgi apparatus. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Note=L-CaBP1 is associated most likely with the cytoskeletal structures, whereas S-CaBP1 is localized at or near the plasma membrane Isoform S-CaBP1: Cytoplasm, cell cortex. Cell membrane; Lipid-anchor. Note=S-CaBP1 is localized at or near the plasma membrane|
|Tissue Location||Retina and brain. Somatodendritic compartment of neurons. Calbrain was found exclusively in brain where it is abundant in the hippocampus, habenular area in the epithalamus and in the cerebellum|
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Provided below are standard protocols that you may find useful for product applications.
The product of this gene belongs to a subfamily of calcium binding proteins, which share similarity to calmodulin. Calcium binding proteins are an important component of calcium mediated cellular signal transduction. Expression of this gene was only detected in retina and brain. Study of the mouse homolog demonstrated that groups of cells expressing this protein are located in the center or inner border of the inner unclear layer of retina. Three alternatively spliced variants encoding different isoforms have been described.
Structural insights into Ca2+-dependent regulation of inositol 1,4,5-trisphosphate receptors by CaBP1. Li C, et al. J Biol Chem, 2009 Jan 23. PMID 19008222.
Ca2+ binding protein-1 inhibits Ca2+ currents and exocytosis in bovine chromaffin cells. Chen ML, et al. J Biomed Sci, 2008 Mar. PMID 17960496.
Analysis of the interacting partners of the neuronal calcium-binding proteins L-CaBP1, hippocalcin, NCS-1 and neurocalcin delta. Haynes LP, et al. Proteomics, 2006 Mar. PMID 16470652.
Structural analysis of Mg2+ and Ca2+ binding to CaBP1, a neuron-specific regulator of calcium channels. Wingard JN, et al. J Biol Chem, 2005 Nov 11. PMID 16147998.
Molecular mechanism for divergent regulation of Cav1.2 Ca2+ channels by calmodulin and Ca2+-binding protein-1. Zhou H, et al. J Biol Chem, 2005 Aug 19. PMID 15980432.
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