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Goat Anti-CACNB4 (internal) Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-CACNB4 (internal) Antibody AF1177b
    AF1177b (0.2 µg/ml) staining of Human Bone Marrow lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O00305
Other Accession NP_001005746, 785, 12298 (mouse), 58942 (rat)
Reactivity Human
Predicted Mouse, Rat, Dog
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 58169 Da
Additional Information
Gene ID 785
Other Names Voltage-dependent L-type calcium channel subunit beta-4, CAB4, Calcium channel voltage-dependent subunit beta 4, CACNB4, CACNLB4
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-CACNB4 (internal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms CACNLB4
Function The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.
Tissue Location Expressed predominantly in the cerebellum and kidney
Research Areas
Citations (0)

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This gene encodes a member of the beta subunit family of voltage-dependent calcium channel complex proteins. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. The protein encoded by this locus plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy (IGE) and juvenile myoclonic epilepsy (JME). Multiple transcript variants encoding different isoforms have been found for this gene.


Replication of previous genome-wide association studies of bone mineral density in premenopausal American women. Ichikawa S, et al. J Bone Miner Res, 2010 Aug. PMID 20200978.
Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. Voss M, et al. BMC Immunol, 2009 Oct 6. PMID 19807924.
A CACNB4 mutation shows that altered Ca(v)2.1 function may be a genetic modifier of severe myoclonic epilepsy in infancy. Ohmori I, et al. Neurobiol Dis, 2008 Dec. PMID 18755274.
[Physiological role of presynaptic Ca2+ channel complexes on neurotransmitter release] Kiyonaka S, et al. Seikagaku, 2008 Jul. PMID 18712068.
Episodic ataxia: SLC1A3 and CACNB4 do not explain the apparent genetic heterogeneity. Graves TD, et al. J Neurol, 2008 Jul. PMID 18446307.

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$ 325.00
Cat# AF1177b
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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