|Application ||WB, E|
|Other Accession||NP_958434, 1265|
|Calculated MW||33697 Da|
|Other Names||Calponin-2, Calponin H2, smooth muscle, Neutral calponin, CNN2|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-Calponin 2 / CNN2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.|
|Tissue Location||Heart and smooth muscle.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene, which can bind actin, calmodulin, troponin C, and tropomyosin, may function in the structural organization of actin filaments. The encoded protein could play a role in smooth muscle contraction and cell adhesion. Two transcript variants encoding different isoforms have been found for this gene.
h2-Calponin is regulated by mechanical tension and modifies the function of actin cytoskeleton. Hossain MM, et al. J Biol Chem, 2005 Dec 23. PMID 16236705.
Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039.
Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. Gevaert K, et al. Nat Biotechnol, 2003 May. PMID 12665801.
Developmentally regulated expression of calponin isoforms and the effect of h2-calponin on cell proliferation. Hossain MM, et al. Am J Physiol Cell Physiol, 2003 Jan. PMID 12388067.
The DNA sequence of human chromosome 21. Hattori M, et al. Nature, 2000 May 18. PMID 10830953.
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