|Application ||IHC, E|
|Other Accession||NP_001158229, 9722, 70729 (mouse), 192363 (rat)|
|Predicted||Mouse, Rat, Cow|
|Calculated MW||56150 Da|
|Other Names||Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein, C-terminal PDZ ligand of neuronal nitric oxide synthase protein, Nitric oxide synthase 1 adaptor protein, NOS1AP, CAPON, KIAA0464|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-CAPON / NOS1AP Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4 (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a cytosolic protein that binds to the signaling molecule, neuronal nitric oxide synthase (nNOS). This protein has a C-terminal PDZ-binding domain that mediates interactions with nNOS and an N-terminal phosphotyrosine binding (PTB) domain that binds to the small monomeric G protein, Dexras1. Studies of the related mouse and rat proteins have shown that this protein functions as an adapter protein linking nNOS to specific targets, such as Dexras1 and the synapsins. Alternative splicing results in multiple transcript variants encoding different isoforms.
A common variant of NOS1AP is associated with QT interval duration in a Chinese population with Type 2 diabetes. Lu J, et al. Diabet Med, 2010 Sep. PMID 20722683.
Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.
Mutation screening of NOS1AP gene in a large sample of psychiatric patients and controls. Delorme R, et al. BMC Med Genet, 2010 Jul 5. PMID 20602773.
Childhood trauma and genetic factors in familial schizophrenia associated with the NOS1AP gene. Husted JA, et al. Schizophr Res, 2010 Aug. PMID 20541371.
Polymorphisms in the NOS1AP gene modulate QT interval duration and risk of arrhythmias in the long QT syndrome. Tom谩s M, et al. J Am Coll Cardiol, 2010 Jun 15. PMID 20538168.
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