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Goat Anti-CARD15 / NOD2 (Internal) Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-CARD15 / NOD2 (Internal) Antibody AF1191a
    AF1191a (0.1 µg/ml) staining of Human Peripheral Blood Mononucleocyte lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9HC29
Other Accession NP_071445, 64127, 257632 (mouse), 291912 (rat)
Reactivity Human
Predicted Mouse, Rat
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 115283 Da
Additional Information
Gene ID 64127
Other Names Nucleotide-binding oligomerization domain-containing protein 2, Caspase recruitment domain-containing protein 15, Inflammatory bowel disease protein 1, NOD2, CARD15, IBD1
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-CARD15 / NOD2 (Internal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NOD2
Synonyms CARD15, IBD1
Function Recognizes muramyl dipeptide (MDP) constituents of bacterial peptidoglycans and plays a key role in gastrointestinal immunity: upon stimulation, binds the proximal adapter receptor- interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3 and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling, leading to activate the transcription of hundreds of genes involved in immune response.
Cellular Location Cytoplasm. Membrane. Basolateral cell membrane
Tissue Location Monocytes-specific.
Research Areas
Citations ( 0 )


This gene is a member of the Nod1/Apaf-1 family and encodes a protein with two caspase recruitment (CARD) domains and six leucine-rich repeats (LRRs). The protein is primarily expressed in the peripheral blood leukocytes. It plays a role in the immune response to intracellular bacterial lipopolysaccharides (LPS) by recognizing the muramyl dipeptide (MDP) derived from them and activating the NFKB protein. Mutations in this gene have been associated with Crohn disease and Blau syndrome.


NOD2 mutations predict the risk for surgery in pediatric-onset Crohn's disease. Lacher M, et al. J Pediatr Surg, 2010 Aug. PMID 20713205.
CARD15 mutations and colorectal cancer in a South European country. Freire P, et al. Int J Colorectal Dis, 2010 Oct. PMID 20676658.
A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM). Romero R, et al. Am J Obstet Gynecol, 2010 Jul 29. PMID 20673868.
Toll-like receptor (TLR) and nucleosome-binding oligomerization domain (NOD) gene polymorphisms and endometrial cancer risk. Ashton KA, et al. BMC Cancer, 2010 Jul 21. PMID 20646321.
NOD2 polymorphisms in clinical phenotypes of common variable immunodeficiency disorders. Packwood K, et al. Clin Exp Immunol, 2010 Jul 14. PMID 20646002.

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$ 325.00
Cat# AF1191a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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