|Application ||IHC, E|
|Other Accession||NP_115976, 84674|
|Calculated MW||116468 Da|
|Other Names||Caspase recruitment domain-containing protein 6, CARD6|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-CARD6 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in apoptosis.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein that contains a caspase recruitment domain (CARD), an antiparallel six-helical bundle that mediates homotypic protein-protein interactions. The encoded protein is a microtubule-associated protein that has been shown to interact with receptor-interacting protein kinases and positively modulate signal transduction pathways converging on activation of the inducible transcription factor NF-kB.
Expression of CARD6, an NF-kappaB activator, in gastric, colorectal and oesophageal cancers. Kim SS, et al. Pathology, 2010 Jan. PMID 20025480.
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Olsen JV, et al. Cell, 2006 Nov 3. PMID 17081983.
CARD tricks: controlling the interactions of CARD6 with RICK and microtubules. Dufner A, et al. Cell Cycle, 2006 Apr. PMID 16582588.
Caspase recruitment domain protein 6 is a microtubule-interacting protein that positively modulates NF-kappaB activation. Dufner A, et al. Proc Natl Acad Sci U S A, 2006 Jan 24. PMID 16418290.
CARD6 is a modulator of NF-kappa B activation by Nod1- and Cardiak-mediated pathways. Stehlik C, et al. J Biol Chem, 2003 Aug 22. PMID 12775719.
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