|Application ||WB, IHC, E|
|Other Accession||NP_006101, 10421|
|Predicted||Mouse, Rat, Dog, Cow|
|Calculated MW||37646 Da|
|Other Names||CD2 antigen cytoplasmic tail-binding protein 2, CD2 cytoplasmic domain-binding protein 2, CD2 tail-binding protein 2, U5 snRNP 52K protein, U5-52K, CD2BP2, KIAA1178|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-CD2BP2 (N Terminus) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome assembly.|
|Cellular Location||Cytoplasm. Nucleus. Note=Predominantly nuclear|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a bi-functional protein. In the cytoplasm, the encoded protein binds the cytoplasmic tail of human surface antigen CD2 via its C-terminal GYF domain, and regulate CD2-triggered T lymphocyte activation. In the nucleus, this protein is a component of the U5 small nuclear ribonucleoprotein complex and is involved in RNA splicing. A pseudogene has been identified on chromosome 7. Alternative splicing results in multiple transcript variants but their biological validity has not been determined.
Defining the human deubiquitinating enzyme interaction landscape. Sowa ME, et al. Cell, 2009 Jul 23. PMID 19615732.
Investigating the functional role of CD2BP2 in T cells. Heinze M, et al. Int Immunol, 2007 Nov. PMID 17906334.
Structural basis for the bifunctionality of the U5 snRNP 52K protein (CD2BP2). Nielsen TK, et al. J Mol Biol, 2007 Jun 15. PMID 17467737.
Large-scale mapping of human protein-protein interactions by mass spectrometry. Ewing RM, et al. Mol Syst Biol, 2007. PMID 17353931.
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Olsen JV, et al. Cell, 2006 Nov 3. PMID 17081983.
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