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Goat Anti-CD32 / FCGR2B Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-CD32 / FCGR2B Antibody AF1217a
    AF1217a (0.3 µg/ml) staining of K562 lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
  • WB - Goat Anti-CD32 / FCGR2B Antibody AF1217a
    HEK293 overexpressing CD32 (RC211982) and probed with AF1217a (mock transfection in first lane), tested by Origene.
  • IHC - Goat Anti-CD32 / FCGR2B Antibody AF1217a
    AF1217a (3.8 µg/ml) staining of paraffin embedded Human Liver. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P31994
Other Accession NP_001002275, 2213
Reactivity Human
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 34044 Da
Additional Information
Gene ID 2213
Other Names Low affinity immunoglobulin gamma Fc region receptor II-b, IgG Fc receptor II-b, CDw32, Fc-gamma RII-b, Fc-gamma-RIIb, FcRII-b, CD32, FCGR2B, CD32, FCG2, IGFR2
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-CD32 / FCGR2B Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms CD32, FCG2, IGFR2
Function Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B- cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis.
Cellular Location Cell membrane; Single-pass type I membrane protein
Tissue Location Is the most broadly distributed Fc-gamma- receptor. Expressed in monocyte, neutrophils, macrophages, basophils, eosinophils, Langerhans cells, B-cells, platelets cells and placenta (endothelial cells). Not detected in natural killer cells
Research Areas
Citations (0)

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The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene.


Dengue hemorrhagic fever is associated with polymorphisms in JAK1. Silva LK, et al. Eur J Hum Genet, 2010 Jun 30. PMID 20588308.
The role of Fc gamma receptors polymorphisms in bullous pemphigoid. Guilabert A, et al. J Am Acad Dermatol, 2010 Jul. PMID 20542180.
Copy number, linkage disequilibrium and disease association in the FCGR locus. Niederer HA, et al. Hum Mol Genet, 2010 Aug 15. PMID 20508037.
An FcgammaRIIb transmembrane polymorphism in Chinese ITP patients. Xu J, et al. Platelets, 2010. PMID 20507212.
SNPs of Fc-gamma receptor genes and chronic periodontitis. Chai L, et al. J Dent Res, 2010 Jul. PMID 20439936.

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$ 325.00
Cat# AF1217a
(40 western blots)
Availability: 7-10 days
Bulk Size
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