|Application ||IHC, E|
|Other Accession||NP_060874, 55803|
|Calculated MW||44349 Da|
|Other Names||Arf-GAP with dual PH domain-containing protein 2, Centaurin-alpha-2, Cnt-a2, ADAP2, CENTA2|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-CENTA2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||GTPase-activating protein for the ADP ribosylation factor family (Potential). Binds phosphatidylinositol 3,4,5- trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). Possesses a stoichiometry of two binding sites for InsP4 with identical affinity.|
|Cellular Location||Cytoplasm. Cell membrane. Note=Constitutively associated with the plasma membrane. Excluded from the nucleus|
|Tissue Location||Highly expressed in placenta, spleen, kidney, skeletal muscle and adrenal gland. Weakly expressed in thyroid, liver, heart, lung, small intestine, peripheral blood leukocytes Not detected in spinal cord, brain, stomach, trachea, colon, lymph node and bone marrow.|
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Provided below are standard protocols that you may find useful for product applications.
The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. Zhao J, et al. BMC Med Genet, 2010 Jun 14. PMID 20546612.
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
RNF135 mutations are not present in patients with Sotos syndrome-like features. Visser R, et al. Am J Med Genet A, 2009 Feb 15. PMID 19291764.
Genetic determinants of height growth assessed longitudinally from infancy to adulthood in the northern Finland birth cohort 1966. Sovio U, et al. PLoS Genet, 2009 Mar. PMID 19266077.
Protein microarray analysis identifies human cellular prion protein interactors. Satoh J, et al. Neuropathol Appl Neurobiol, 2009 Feb. PMID 18482256.
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