|Application ||WB, E|
|Other Accession||NP_055531, 9744, 216859 (mouse)|
|Predicted||Mouse, Rat, Dog, Cow|
|Calculated MW||81536 Da|
|Other Names||Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1, Centaurin-beta-1, Cnt-b1, ACAP1, CENTB1, KIAA0050|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-CENTB1 / ACAP1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. Required for regulated export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration.|
|Cellular Location||Recycling endosome membrane; Peripheral membrane protein; Cytoplasmic side|
|Tissue Location||Highest level in lung and spleen. Low level in heart, kidney, liver and pancreas.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
Substrate specificities and activities of AZAP family Arf GAPs in vivo. Cuthbert EJ, et al. Am J Physiol Cell Physiol, 2008 Jan. PMID 18003747.
An ACAP1-containing clathrin coat complex for endocytic recycling. Li J, et al. J Cell Biol, 2007 Jul 30. PMID 17664335.
Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. Wu C, et al. Proteomics, 2007 Jun. PMID 17474147.
Cooperation of phosphoinositides and BAR domain proteins in endosomal tubulation. Shinozaki-Narikawa N, et al. Traffic, 2006 Nov. PMID 17010122.
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