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Goat Anti-CGI58 / ABHD5 Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-CGI58 / ABHD5 Antibody AF1233a
    AF1233a (0.2 µg/ml) staining of NIH3T3 lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8WTS1
Other Accession NP_057090, 51099, 67469 (mouse), 316122 (rat)
Reactivity Human, Mouse, Cow
Predicted Rat, Dog
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 39096 Da
Additional Information
Gene ID 51099
Other Names 1-acylglycerol-3-phosphate O-acyltransferase ABHD5,, Abhydrolase domain-containing protein 5, Lipid droplet-binding protein CGI-58, ABHD5, NCIE2
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-CGI58 / ABHD5 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ABHD5
Synonyms NCIE2
Function Lysophosphatidic acid acyltransferase which functions in phosphatidic acid biosynthesis. May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2. Involved in keratinocyte differentiation.
Cellular Location Cytoplasm. Lipid droplet. Note=Colocalized with PLIN and ADRP on the surface of lipid droplets. The localization is dependent upon the metabolic status of the adipocytes and the activity of PKA (By similarity).
Tissue Location Widely expressed in various tissues, including lymphocytes, liver, skeletal muscle and brain. Expressed by upper epidermal layers and dermal fibroblasts in skin, hepatocytes and neurons (at protein level).
Research Areas
Citations (0)

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The protein encoded by this gene belongs to a large family of proteins defined by an alpha/beta hydrolase fold, and contains three sequence motifs that correspond to a catalytic triad found in the esterase/lipase/thioesterase subfamily. It differs from other members of this subfamily in that its putative catalytic triad contains an asparagine instead of the serine residue. Mutations in this gene have been associated with Chanarin-Dorfman syndrome, a triglyceride storage disease with impaired long-chain fatty acid oxidation.


High frequency of ETFDH c.250G>A mutation in Taiwanese patients with late-onset lipid storage myopathy. Lan MY, et al. Clin Genet, 2010 Mar 29. PMID 20370797.
Neutral lipid storage disease: genetic disorders caused by mutations in adipose triglyceride lipase/PNPLA2 or CGI-58/ABHD5. Schweiger M, et al. Am J Physiol Endocrinol Metab, 2009 Aug. PMID 19401457.
Chanarin-Dorfman syndrome: deficiency in CGI-58, a lipid droplet-bound coactivator of lipase. Yamaguchi T, et al. Biochim Biophys Acta, 2009 Jun. PMID 19061969.
CGI-58 is an alpha/beta-hydrolase within lipid transporting lamellar granules of differentiated keratinocytes. Akiyama M, et al. Am J Pathol, 2008 Nov. PMID 18832586.
CGI-58, the causative gene for Chanarin-Dorfman syndrome, mediates acylation of lysophosphatidic acid. Ghosh AK, et al. J Biol Chem, 2008 Sep 5. PMID 18606822.

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$ 325.00
Cat# AF1233a
(40 western blots)
Availability: 7-10 days
Bulk Size
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