|Application ||WB, E|
|Other Accession||NP_001814, 1152, 12709 (mouse)|
|Predicted||Mouse, Rat, Pig, Dog, Cow|
|Calculated MW||42644 Da|
|Other Names||Creatine kinase B-type, 18.104.22.168, B-CK, Creatine kinase B chain, CKB, CKBB|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-CKB / Brain Creatine Kinase Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in brain as well as in other tissues, and as a heterodimer with a similar muscle isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. A pseudogene of this gene has been characterized.
Reduced creatine kinase B activity in multiple sclerosis normal appearing white matter. Steen C, et al. PLoS One, 2010 May 25. PMID 20520825.
Reduced creatine kinase as a central and peripheral biomarker in Huntington's disease. Kim J, et al. Biochim Biophys Acta, 2010 Jul-Aug. PMID 20460152.
Defining the human deubiquitinating enzyme interaction landscape. Sowa ME, et al. Cell, 2009 Jul 23. PMID 19615732.
Proteome analysis of schizophrenia patients Wernicke's area reveals an energy metabolism dysregulation. Martins-de-Souza D, et al. BMC Psychiatry, 2009 Apr 30. PMID 19405953.
Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia. Martins-de-Souza D, et al. Eur Arch Psychiatry Clin Neurosci, 2009 Apr. PMID 19165527.
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