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Goat Anti-Cofilin 2 (muscle) Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-Cofilin 2 (muscle) Antibody AF1259a
    AF1259a (0.003 µg/ml) staining of Human Skeletal Muscle lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
  • WB - Goat Anti-Cofilin 2 (muscle) Antibody AF1259a
    AF1259a (0.001 µg/ml) staining of Rat Skeletal Muscle lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
  • WB - Goat Anti-Cofilin 2 (muscle) Antibody AF1259a
    HEK293 overexpressing Human Muscle Cofilin 2 (RC222215) and probed with AF1259a (mock transfection in first lane), tested by Origene.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9Y281
Other Accession NP_619579, 1073
Reactivity Human, Mouse, Rat
Predicted Pig, Dog
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 18737 Da
Additional Information
Gene ID 1073
Other Names Cofilin-2, Cofilin, muscle isoform, CFL2
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-Cofilin 2 (muscle) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CFL2
Function Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods (By similarity).
Cellular Location Nucleus matrix. Cytoplasm, cytoskeleton
Tissue Location Isoform CFL2b is expressed predominantly in skeletal muscle and heart. Isoform CFL2a is expressed in various tissues
Research Areas
Citations (0)

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This gene encodes an intracellular protein that is involved in the regulation of actin-filament dynamics. This protein is a major component of intranuclear and cytoplasmic actin rods. It can bind G- and F-actin in a 1:1 ratio of cofilin to actin, and it reversibly controls actin polymerization and depolymerization in a pH-dependent manner. Mutations in this gene cause nemaline myopathy type 7, a form of congenital myopathy. Alternative splicing results in multiple transcript variants.


Muscle LIM protein interacts with cofilin 2 and regulates F-actin dynamics in cardiac and skeletal muscle. Papalouka V, et al. Mol Cell Biol, 2009 Nov. PMID 19752190.
Cofilin activation in peripheral CD4 T cells of HIV-1 infected patients: a pilot study. Wu Y, et al. Retrovirology, 2008 Oct 17. PMID 18928553.
Nemaline myopathy with minicores caused by mutation of the CFL2 gene encoding the skeletal muscle actin-binding protein, cofilin-2. Agrawal PB, et al. Am J Hum Genet, 2007 Jan. PMID 17160903.
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Olsen JV, et al. Cell, 2006 Nov 3. PMID 17081983.
Cofilin cross-bridges adjacent actin protomers and replaces part of the longitudinal F-actin interface. Kudryashov DS, et al. J Mol Biol, 2006 May 5. PMID 16530787.

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$ 325.00
Cat# AF1259a
(40 western blots)
Availability: 7-10 days
Bulk Size
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