|Application ||WB, E|
|Other Accession||NP_112729, 10087, 68018 (mouse)|
|Calculated MW||70835 Da|
|Other Names||Collagen type IV alpha-3-binding protein, Ceramide transfer protein, hCERT, Goodpasture antigen-binding protein, GPBP, START domain-containing protein 11, StARD11, StAR-related lipid transfer protein 11, COL4A3BP, CERT, STARD11|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-COL4A3BP (aa662-672) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner.|
|Cellular Location||Cytoplasm. Golgi apparatus. Endoplasmic reticulum Note=Preferentially localized to the Golgi apparatus|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a kinase that specifically phosphorylates the N-terminal region of the non-collagenous domain of the alpha 3 chain of type IV collagen, known as the Goodpasture antigen. Goodpasture disease is the result of an autoimmune response directed at this antigen. One isoform of this protein is also involved in ceramide intracellular transport. Three transcript variants encoding different isoforms have been found for this gene.
Human biliverdin reductase suppresses Goodpasture antigen-binding protein (GPBP) kinase activity: the reductase regulates tumor necrosis factor-alpha-NF-kappaB-dependent GPBP expression. Miralem T, et al. J Biol Chem, 2010 Apr 23. PMID 20177069.
Crystal structures of the CERT START domain with inhibitors provide insights into the mechanism of ceramide transfer. Kudo N, et al. J Mol Biol, 2010 Feb 19. PMID 20036255.
Defining the human deubiquitinating enzyme interaction landscape. Sowa ME, et al. Cell, 2009 Jul 23. PMID 19615732.
Causes of food-induced anaphylaxis in Italian adults: a multi-centre study. Asero R, et al. Int Arch Allergy Immunol, 2009. PMID 19494524.
Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae. Lowe JK, et al. PLoS Genet, 2009 Feb. PMID 19197348.
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