|Application ||WB, E|
|Other Accession||NP_000177, 3075|
|Calculated MW||139096 Da|
|Other Names||Complement factor H, H factor 1, CFH, HF, HF1, HF2|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-Complement factor H Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||HF, HF1, HF2|
|Function||Factor H functions as a cofactor in the inactivation of C3b by factor I and also increases the rate of dissociation of the C3bBb complex (C3 convertase) and the (C3b)NBB complex (C5 convertase) in the alternative complement pathway.|
|Tissue Location||Expressed by the liver and secreted in plasma.|
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Provided below are standard protocols that you may find useful for product applications.
This gene is a member of the Regulator of Complement Activation (RCA) gene cluster and encodes a protein with twenty short concensus repeat (SCR) domains. This protein is secreted into the bloodstream and has an essential role in the regulation of complement activation, restricting this innate defense mechanism to microbial infections. Mutations in this gene have been associated with hemolytic-uremic syndrome (HUS) and chronic hypocomplementemic nephropathy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Genetic variation in complement factor H and risk of coronary heart disease: Eight new studies and a meta-analysis of around 48,000 individuals. Sofat R, et al. Atherosclerosis, 2010 Jul 29. PMID 20708732.
Genome-wide association study identifies variants in the CFH region associated with host susceptibility to meningococcal disease. Davila S, et al. Nat Genet, 2010 Sep. PMID 20694013.
Joint Effect of Cigarette Smoking, CFH and LOC387715/HTRA1 Polymorphisms on Polypoidal Choroidal Vasculopathy. Nakanishi H, et al. Invest Ophthalmol Vis Sci, 2010 Aug 4. PMID 20688737.
Complement Factor H and High-Temperature Requirement A-1 Genotypes and Treatment Response of Age-related Macular Degeneration. Tsuchihashi T, et al. Ophthalmology, 2010 Jul 31. PMID 20678803.
R102G polymorphism of the C3 gene associated with exudative age-related macular degeneration in a French population. Zerbib J, et al. Mol Vis, 2010 Jul 15. PMID 20664795.
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